ea0063gp217 | Gestational and Type 1 Diabetes | ECE2019
Crispim Daisy
, Pellenz Felipe Mateus
, Duarte Guilherme
, Dieter Cristine
, Souza Bianca de
Background and Aims: Type 1 diabetes mellitus (T1DM) is caused by an autoimmune destruction of pancreatic beta cells, which renders patients insulin-dependent for life. The disease arises from a complex interaction among several genetic and environmental factors. To date, single nucleotide polymorphisms (SNPs) in >50 genes have been associated with T1DM, with HLA class II SNPs having the greatest impact on disease susceptibility. Other loci have minor effects on T...